All expectant mother's have a risk of having a child affected with chromosomal abnormalities, the commonest being Trisomy 21 or Down Syndrome.
Diagnosed in 1 among 800 babies, Down syndrome is the commonest genetic cause of intellectual disability.
Traditional biochemical screening tests detect only 70% of affected children and have a high false positive rate of 1 in 20.
Confirmatory tests like amniocentesis or chorionic villous biopsy are associated with a procedural risk of miscarriage.
CHROME estimates this chromosomal risk more accurately and safely using maternal blood!
Cell free DNA fragments (cf-DNA) are short fragments of DNA found circulating in the blood.
During pregnancy, maternal blood contains both fetal (unborn baby) as well as maternal cell free DNA fragments.
Maternal blood collected in specialized tubes is analyzed using these fetal fragments to detect chromosomal aneuploidies in the fetus.
As opposed to other Non Invasive Prenatal Tests, CHROME can test:
> All 23 chromosomes
>As early as 9 weeks gestation
>Up-to 2% fetal fraction
